POEMS syndrome is a rare multisystemic disease, characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes.The presence of polyneuropathy and monoclonal plasma cell proliferation is mandatory for the diagnosis of typical POEMS syndrome.However, some patients lack one of the mandatory features and are classif
Background and Objectives: A recent clinical trial has demonstrated that breast cancer with low-HER2 expression levels responds to Mirror Covers trastuzumab deruxtecan treatment.This has prompted a re-evaluation of HER2-targeted therapies in the HER2-negative group.Further research is required in the form of more detailed information about HER2-neg
ABSTRACT Cancer related to hereditary syndromes corresponds to approximately 5-10% of all tumors.Among those from the genitourinary system, many tumors had been JADE PEARL RICE RAMEN identified to be related to genetic syndromes in the last years with the advent of new molecular genetic tests.New entities were described or better characterized, esp
Systems vaccinology studies have been used to build computational models that predict individual vaccine responses Futon and identify the factors contributing to differences in outcome.Comparing such models is challenging due to variability in study designs.To address this, we established a community resource to compare models predicting B.pertussi
Abstract Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction.However, the molecular and cellular mechanisms underlying median eminence development and pubertal timing are incompletely understood.Here we show that Semaphorin-6A is strongly expre